Endocrine Abstracts

Wegener’s granulomatosis is characterized by necrotizing granulomatous vasculitis. It occurs initially in a localized form, disseminates in various degrees and particularly involves the respiratory tract and kidneys. It is an ANCA-associated vasculitis, a systemic disease of autoimmune aetiology. Recently vitamin D deficiency has been associated with the development of autoimmunity. The aim was to present a case of Wegener’s granulomatosis in a patient with vitamin D...

Site-discordance in bone mineral density (BMD) assessment is common and affects patient categorization. Greater number of osteoporotic sites correlates with lower T score at each index site. The effect of BMD measurement at the contralateral femur on osteoporosis diagnosis has been previously evaluated.The aim of the study was to investigate the effect of BMD measurement at the contralateral femur on osteoporosis diagnosis.M...

Biological agents have been successfully introduced in the therapeutics of autoimmune diseases, in particular rheumatoid arthritis and ankylosing spondylitis. However, their use has been found to increase the risk of serious infections and neoplasms. Infliximab, a neutralizing antibody to tumor necrosis factor-alpha, appears to be effective therapy in ankylosing spondylitis. Tumor necrosis factor (TNF) plays an important role in host defense and tumor growth control. Therefore...

Introduction: Vitamin D deficiency is associated with the development of osteomalacia, as it decreases intestinal calcium absorption and bone mineralization. However, severe vitamin D deficiency may also be correlated with secondary hyperparathyroidism which induces osteoporosis. In addition, it induces muscular dysfunction which along with frailty in old age it may induce falls.Aim: The aim was to present a group of patients with severe vitamin D defici...

Introduction: Vitamin D has been found to be associated with multiple chronic diseases, including diabetes mellitus type 1 and 2, rheumatoid arthritis, systemic lupus erythematosus and other autoimmune diseases. Low vitamin D levels have also been observed in patients with obesity.Aim: The aim was to study vitamin D levels in patients with morbid obesity.Methods: In a group of 32 patients with morbid obesity, BMI 41.77±1.15 (m...

Introduction: Graves’ disease is a multi-system autoimmune disease characterized by hyperthyroidism, ophthalmopathy and pretibial myxedema. The disease presents with hyperthyroidism or more rarely with ophthalmopathy. It runs a various course and many times during its natural course permanent hypothyroidism may ensue.Aim: The aim was to describe the case of a patient with Graves’ disease presenting with ophthalmopathy and subclinical hypothyroi...

Primary hyperaldosteronism may be due to an adrenal adenoma and is an increasingly recognized cause of secondary arterial hypertension. The disease causes hypokalemia and is usually treated surgically by excision of the adrenal adenoma. However, it appears that it may present with a clinical profile without arterial hypertension. The aim was to describe three cases of primary hyperaldosteronism who presented with hypokalemia and an adrenal adenoma with normal blood pressure. A...

Morbid obesity is accompanied by multiple comorbidities and may be associated with a high mortality risk. Cardiac manifestations accompany morbid obesity and may account for the increased morbidity and mortality risk which accompanies the disorder. However, cardiac insufficiency as the first cardiovascular manifestation in morbid obesity is a less recognized comorbidity. The aim was to describe cardiac insufficiency as the first cardiovascular disease manifestation in morbid o...

Euthyroid sick syndrome also known as nonthyroidal illness syndrome is the reaction of the thyroid gland to severe disease. The SARS-CoV-2 virus affects the thyroid gland and may cause subacute thyroiditis, autoimmune Hashimoto’s thyroiditis, Graves’ disease, exacerbation of Graves’ disease and a form of silent thyroiditis. The aim was to study thyroid hormone levels and identify the presence of euthyroid sick syndrome in the context of severe SARS-CoV-2 disease...

Introduction: The SARS-CoV-2 virus has severely affected humanity. The disease causes pneumonia which may be severe. In many cases, patients, especially if there are comorbidities, may have a fatal outcome. The disease affects all organs and the variability of its manifestations has attracted intense scientific interest. Aim: The aim of the study was to describe the case of a patient who developed subacute thyroiditis after infection with the SARS-CoV-2 ...